| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 21/01/25 18.45 | AS Monaco | Aston Villa | 1:0 |
| 21/01/25 18.45 | Atalanta | SK Sturm Graz | 5:0 |
| 21/01/25 21.00 | FC Liverpool | OSC Lille | 2:1 |
| 21/01/25 21.00 | Atletico Madrid | Bayer 04 Leverkusen | 2:1 |
| 21/01/25 21.00 | Club Brügge | Juventus | 0:0 |
| 21/01/25 21.00 | Stella Rossa Belgrado | PSV Eindhoven | 2:3 |
| 21/01/25 21.00 | SK Slovan Bratislava | VfB Stoccarda | 1:3 |
| 21/01/25 21.00 | Bologna | Borussia Dortmund | 2:1 |
| 21/01/25 21.00 | Benfica Lisbona | FC Barcellona | 4:5 |
| 22/01/25 18.45 | Shakhtar Donezk | Stade Brest 29 | -:- |
| 22/01/25 18.45 | RB Lipsia | Sporting Lisbona | -:- |
| 22/01/25 21.00 | FC Arsenal | Dinamo Zagabria | -:- |
| 22/01/25 21.00 | Milan | FC Girona | -:- |
| 22/01/25 21.00 | Real Madrid | FC Red Bull Salisburgo | -:- |
| 22/01/25 21.00 | Paris St. Germain | Manchester City | -:- |
| 22/01/25 21.00 | Celtic Glasgow | Young Boys Berna | -:- |
| 22/01/25 21.00 | Feyenoord Rotterdam | FC Bayern Monaco | -:- |
| 22/01/25 21.00 | Sparta Praga | Inter | -:- |